Your cart is empty.
Thank You For
Your Message!
We'll get back to you as soon as possible.
We’ll be in touch
Just leave your name and email. A member of the Medovie team will be in touch soon. If you’d like to DM us, that works too.
Magazine
June 10, 2024
In the realm of autoimmune disorders, a perplexing and intricate connection exists between psoriasis and multiple sclerosis (MS), two seemingly distinct conditions that share a common thread within the intricate web of the immune system.
While psoriasis manifests as a chronic skin disorder, and MS presents as a neurological disorder affecting the central nervous system, recent research has unveiled intriguing links between these seemingly unrelated ailments.
This systematic review of the intricate relationship between psoriasis and MS not only sheds light on the complex interplay of immune responses but also holds the potential to unravel novel insights into the underlying mechanisms that drive these disorders, and potentially other autoimmune diseases.
Understanding this connection may pave the way for more comprehensive treatment strategies, ultimately enhancing the quality of life for those grappling with these challenging conditions.
Join us as we explore the hidden connection between psoriasis and multiple sclerosis, unraveling the complex web that connects these seemingly disparate conditions.
Psoriasis is a skin condition characterized by red, itchy, and scaly patches on the skin. Here, the immune system gets mistakenly triggered and begins attacking healthy skin cells, thereby resulting in an overactive and overproduction of skin cells. This results in the buildup of thick, silvery scales and the formation of patches on the skin’s surface. Psoriasis on elbows, knees, scalp, lower back, and nails are some of the places where the autoimmune disease occurs.
On the other hand, Multiple Sclerosis is a chronic neurological disorder that affects the central nervous system. It occurs when the immune system mistakenly attacks the protective covering of nerve fibers, known as myelin. This results in inflammatory pathways and damage to the nerves, disrupting the normal flow of electrical impulses between the brain and the rest of the body.
The symptoms of MS can vary widely from person to person and may include fatigue, difficulty walking, muscle weakness, numbness or tingling, problems with coordination and balance, as well as cognitive and emotional changes.
Although these chronic inflammatory diseases have different manifestations and affect different parts of the body, they share some common underlying mechanisms. Both conditions are believed to be caused by an abnormal immune response. In psoriasis, immune cells called T-cells are activated and produce cytokines that trigger overactive skin cell production resulting in inflammation. Similarly, in MS, immune cells attack the myelin sheath surrounding nerve fibers, leading to inflammation and damage.
According to the 2022 psoriasis statistics, the skin condition affects around 2-3% of the global population, making it one of the most common autoimmune diseases. It can occur at any age but is most commonly diagnosed in individuals between the ages of 15 and 35.
The prevalence of psoriasis varies among different populations and geographical regions, with higher rates reported in countries with colder climates. Individuals with a family history of such autoimmune disorders are more susceptible to developing the disorder themselves.
On the other hand, multiple sclerosis statistics from a 2020 report states that the condition affects approximately 2.3 million worldwide, making it less common than psoriasis. The prevalence of MS also varies among different populations and geographical regions, with higher rates reported in countries further away from the equator. It is more commonly diagnosed in individuals between the ages of 20 and 40, and women are generally more affected than men. Like psoriasis, having a family history of MS increases the risk of developing the condition.
Certain similarities between these two conditions warrant further exploration. One of the main similarities between psoriasis and MS is that they are both chronic autoimmune diseases. This means that the body’s immune system mistakenly attacks healthy cells and tissues, leading to inflammation and damage. In psoriasis, the immune system attacks the skin cells, resulting in the characteristic red, scaly patches. In MS, the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to a range of neurological symptoms.
Another similarity between psoriasis and MS is that both conditions have a genetic component. Research on the link and risks between MS and psoriasis reveal that individuals with a family history of psoriasis or MS are more likely to develop these conditions themselves. This suggests that certain genetic factors may predispose individuals to develop autoimmune diseases such as psoriasis or MS. However, it is important to note that having a genetic predisposition does not guarantee the development of the condition, as environmental factors also play a significant role in disease onset.
Furthermore, both psoriasis and MS can have a significant impact on an individual’s quality of life. Psoriasis can cause physical discomfort, itching, pain, and embarrassment due to the visible nature of the skin lesions. It can also lead to psychological distress and a negative body image, affecting social interactions and self-esteem. Similarly, MS can cause a range of physical symptoms such as fatigue, muscle weakness, difficulty walking, and problems with coordination. These symptoms can significantly impair a person’s ability to perform daily activities and can also lead to emotional and psychological challenges.
The immune system plays a critical role in both psoriasis and multiple sclerosis. The immune system is responsible for protecting the body against harmful substances and diseases. However, in the case of psoriasis and multiple sclerosis, the immune system becomes overactive and begins to attack healthy cells in the body.
In the case of psoriasis, the immune system mistakenly identifies healthy skin cells as foreign invaders and triggers an inflammatory response. This leads to the rapid production of new skin cells, resulting in the characteristic symptoms of psoriasis such as red, scaly patches on the skin. The exact cause of psoriasis is still unknown, but it is believed to be a combination of genetic and environmental factors that trigger an abnormal immune response.
Similarly, in multiple sclerosis, the immune system mistakenly attacks the protective covering of nerve fibers called myelin. Myelin is essential for the proper transmission of nerve impulses. When myelin is damaged, it disrupts communication between the brain and other parts of the body, leading to a wide range of MS symptoms such as fatigue, muscle weakness, and difficulty with coordination.
The involvement of the immune system in both psoriasis and multiple sclerosis highlights the complex nature of these conditions. Researchers are still trying to understand the underlying mechanisms that lead to these abnormal immune responses. By better understanding how the immune system functions in these conditions, scientists hope to develop more effective treatments that can target specific aspects of the immune response.
Genetic factors are known to contribute to the development of both psoriasis and multiple sclerosis. Several genes have been identified to be associated with psoriasis and MS. The major histocompatibility complex (MHC) genes, specifically human leukocyte antigen (HLA)-Cw6, are strongly linked to psoriasis and psoriatic arthritis. Other genes, such as IL23R and TNIP1, have also been implicated in the development of psoriasis. These genetic risk variants can affect the immune response and lead to an abnormal activation of immune cells in the skin, resulting in inflammation and the characteristic symptoms of psoriasis.
Similarly, in the case of multiple sclerosis, several genes have been identified as non-environmental risk factors for the disease. The HLA-DRB1 gene is the most well-known genetic risk factor for MS. Other genes, such as IL2RA and IL7R, have also been found to be associated with an increased risk of developing MS. These genetic variations can affect the immune system’s ability to regulate inflammation and can lead to an abnormal immune response against the central nervous system.
The impact of these genetic factors on psoriasis and MS is complex and multifactorial. While having certain genetic variations may increase the risk of developing these diseases, it is not a guarantee that an individual will develop them. Environmental factors, such as infections and stress, also play a role in triggering the onset and exacerbation of these diseases.
While genetic factors play a significant role, environmental triggers also contribute to the development of psoriasis and multiple sclerosis. One potential shared environmental trigger for both psoriasis and MS is vitamin D deficiency. Studies show that Vitamin D and psoriasis are linked and have an impact on regulating the immune system and maintaining healthy skin. Reports show that individuals with psoriasis and MS tend to have lower levels of vitamin D compared to those without these conditions.
Another potential environmental trigger is exposure to certain infections. Infections, particularly those caused by bacteria or viruses, can stimulate the immune system and trigger an inflammatory response. This inflammation can worsen existing psoriasis symptoms or contribute to the development of MS. For example, streptococcal infections, such as strep throat, might be a trigger for psoriasis flare-ups. Similarly, certain viral infections, such as the Epstein-Barr virus, have been linked to an increased risk of developing MS.
Stress is another environmental factor that has been implicated in both psoriasis and MS. Chronic stress can disrupt the immune system and contribute to inflammation. Studies have shown that individuals with psoriasis and MS often report higher levels of stress compared to those without these conditions. It is thought that stress may exacerbate existing symptoms or increase the risk of developing these diseases.
Managing the symptoms and improving the quality of life for individuals with both psoriasis and multiple sclerosis can be challenging. Currently, there is no cure for either condition, but various treatment options are available to alleviate symptoms and slow the progression of the disease.
One treatment option for patients with both psoriasis and multiple sclerosis is the use of systemic medications. These medications work by suppressing the immune system and reducing inflammation, which can help alleviate symptoms of both conditions. Related disorders such as psoriatic arthritis can also be treated in similar ways. Examples of systemic medications commonly used in the treatment of psoriasis and multiple sclerosis include methotrexate and biologic agents such as adalimumab and ustekinumab.
Another treatment option for patients with both conditions is phototherapy. Phototherapy involves exposing the skin to ultraviolet (UV) radiation to slow down the production of skin cells and reduce inflammation. This can help improve symptoms of psoriasis and may also have a positive effect on multiple sclerosis. UVB phototherapy is commonly used in the treatment of psoriasis, while UVA phototherapy with a photosensitizing agent called psoralen is sometimes used for patients with multiple sclerosis.
In addition to systemic medications and phototherapy, lifestyle modifications can also play a role in managing symptoms of both psoriasis and multiple sclerosis. For example, maintaining a healthy diet and engaging in regular exercise can help support overall immune function and reduce inflammation. Stress management techniques such as meditation or yoga may also be beneficial, as stress has been shown to exacerbate symptoms of both psoriasis and multiple sclerosis.
Living with both psoriasis and multiple sclerosis can significantly impact an individual’s quality of life. The physical discomfort, mobility issues, and psychological impact of these conditions can be challenging to navigate.
In addition to the physical symptoms, psoriasis can also have a profound impact on an individual’s mental and emotional well-being. Many people with psoriasis experience feelings of self-consciousness, embarrassment, and isolation due to the visible nature of the condition. Managing symptoms and improving the quality of life for individuals with psoriasis involves a multi-faceted approach. Connecting with support groups or seeking therapy can help individuals cope with the emotional toll of living with psoriasis.
MS is a progressive disease that can vary greatly in severity and progression from person to person. Managing symptoms and improving the quality of life for individuals with MS requires a comprehensive approach that addresses both physical and emotional needs. Emotional support is crucial for individuals with MS, as the unpredictable nature of the condition can cause significant anxiety. Connecting with support groups or seeking therapy can provide individuals with MS with the necessary tools to cope with the challenges they face on a day-to-day basis.
The hidden connection between psoriasis and multiple sclerosis offers a fascinating area of research that has the potential to enhance our understanding of autoimmune diseases as a whole. Further research is needed to unravel the intricate mechanisms that link these conditions and explore potential shared therapeutic targets.
The link between psoriasis and multiple sclerosis is a captivating area of study that sheds light on the complex interactions within the immune system and the underlying mechanisms of autoimmune diseases. As research progresses, it is essential to raise awareness and foster collaboration to improve the lives of individuals affected by psoriasis, multiple sclerosis, and other related conditions.
And helping you achieve a more holistic way of living in this journey is Medovie, a natural skincare company offering naturally safe and effective skincare solutions for chronic skin conditions like psoriasis, eczema, and other skin troubles.
Medovie’s innovative 3HX™ formula shows recognizable results in managing chronic skin troubles which is a testament to years of advanced research combined with traditional Chinese Medicine to give you the ideal formulation that suits your irritated skin needs. Discover the psoriasis products from Medovie, including shampoos, scalp lotions, derma creams, and supplement capsules, that can help manage your symptoms and nourish sensitive skin.
Nadav Shraibom, MSc in Traditional Chinese Medicine, is the Scientific Founder at Medovie, pioneering skincare solutions for chronic skin conditions. With over two decades of expertise in TCM, he blends ancient wisdom with modern research to craft safe and effective products. Dedicated to elevating skincare standards, Nadav leads a team in developing innovative formulas under the ‘Medovie Standard’, ensuring the highest quality and efficacy for users worldwide.
Thank You For
Your Message!
We'll get back to you as soon as possible.
We’ll be in touch
Just leave your name and email. A member of the Medovie team will be in touch soon. If you’d like to DM us, that works too.